The presentations contain clinical and nonclinical studies of tedizolid, including results from the ESTABLISH 1 trial. This is the first Phase 3 study of tedizolid in patients with acute bacterial skin and skin structure infections (ABSSSI).
Online PR News – 07-September-2012 –SAN FRANCISCO, Sept. 7, 2012 (GLOBE NEWSWIRE) -- ICAAC 2012 -- Trius Therapeutics, Inc. (Nasdaq:TSRX) announced today that the results of multiple studies from its drug development programs, including its lead antibiotic drug candidate tedizolid phosphate (TR-701), will be presented in poster and podium presentations at the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) meeting in San Francisco from September 9 to September 12, 2012.
The presentations contain clinical and nonclinical studies of tedizolid, including results from the ESTABLISH 1 trial. This is the first Phase 3 study of tedizolid in patients with acute bacterial skin and skin structure infections (ABSSSI). Additional preclinical abstracts include advances in Trius' GyrB/ParE antibacterial program, which targets gram-negative pathogens. This is a class of bacteria rapidly developing resistance to existing antibiotics, and for which there are few new antibacterial agents in development.
The presentations are as follows:
Sunday, September 9th
Poster Presentations 010 Multi-Center Surveillance Studies (11:30 a.m. 1:30 p.m.)
C2-142: In Vitro Activity of Tedizolid and Radezolid against Linezolid-Resistant Gram-positive Clinical Isolates with Genetically Characterized Resistance Mechanisms; E. Cercenado, M. Marνn, B. Gama, C. Iglesias, E. Bouza
Monday, September 10th
Poster Presentation 093 Cornucopia of In Vitro Activity (11:15 a.m. 1:15 p.m.)
E-778: Comparison of Tedizolid (TZD) In Vitro Activity with that of Other Key Gram Positive Agents Against Recent Enterococcal and Streptococcal Isolates; D. Sahm, J. Deane, A. Simenauer, K. Bartizal, K. J. Shaw
Tuesday, September 11th
Poster Presentations 174 In Vitro Activity Versus Staphylococcal (11:15 a.m. 1:15 p.m.)
E-1479: In Vitro Activity Profile of Tedizolid (TZD) and Correlations with Linezolid (LZD) Activity Against Recent Staphylococcal Isolates; J. Deane, A. Simenauer, K. Bartizal, K. J. Shaw, D. Sahm
Poster Presentations 163 Pharmacokinetics/Pharmacodynamics of New and Old Oxazolidinones (11:15 a.m. 1:15 p.m.)
A-1291: Study of the Cellular Uptake and Subcellular Distribution of the Oxazolidinone Tedizolid (TZD) in Murine J774 Macrophages: Lack of Association with Mitochondria; D. Das, A. Lambert, P. Tulkens, G. Muccioli, F. Van Bambeke
A-1292: Safety and Pharmacokinetics After Single Oral and IV Administration of Tedizolid Phosphate in Adolescent Patients; H. Dreskin, K.A. Muρoz, S. Minassian, J. Bradley, A. Arrieta, E. Capparelli, R. Jacobs, E. Fang, S. Flanagan, P. Prokocimer
A-1293: Safety and Pharmacokinetics of Single Oral Administration of Tedizolid Phosphate in Healthy Elderly Subjects and Adult Control Subjects; H. Dreskin, D. Subich, K. Muρoz, S. Flanagan, S. Minassian, E. Fang, P. Prokocimer
A-1294: A Phase 1 Study of Intravenously Administered Tedizolid Phosphate in Subjects with Advanced Renal Impairment; S. Flanagan, D. Morris, T. Boyea, H. Dreskin, S. Minassian, H. Alcorn, T. Marbury, M. Abdelhameed, E. Fang, P. Prokocimer
A-1295: A Phase 1 Study of Orally Administered Tedizolid Phosphate in Subjects with Moderate or Severe Hepatic Impairment; S. Flanagan, T. Boyea, H. Dreskin, S. Minassian, T. Marbury, H. Alcorn, E. Fang, P. Prokocimer
A-1295a: Lack of MAO Inhibition by Tedizolid Phosphate in Clinical and Nonclinical Studies; S. Flanagan, S. Minassian, E. Fang, H. Dreskin, R. Weaver, K. Bartizal, P. Prokocimer
Poster Presentations 189 Novel Agents and Insights in Skin and Soft Tissue Infections (11:15 a.m. 1:15 p.m.)
L1-1664: Safety Profile of Tedizolid Phosphate Compared to Linezolid in a Phase 3 ABSSSI Study; E. Fang, C. De Anda, A. Das, P. Prokocimer
L1-1665: Comparison of Investigator Assessed and Programmatic Clinical Outcomes of Tedizolid Phosphate vs. Linezolid in a Phase 3 Study in Patients with ABSSSI; C. De Anda, E. Fang, S. Green, P. Mehra, P. Prokocimer
Wednesday, September 12th
Poster Presentations 245 In Vitro Activity for Mycobacteria (9:15 a.m. 11:15 a.m.)
E-1995: In Vitro Activities of Tedizolid Compared to Linezolid against Mycobacterium fortuitum; M. H. Cynamon, M. Sklaney
Poster Presentations 247 Novel Inhibitors of Bacterial GyrB/ParE Topoisomerase Subunits (9:15 a.m. 11:15 a.m.)
F-2017: Antibacterial Agents Targeting DNA Gyrase B and Topoisomerase IV: Discovery of a New Class by Structure-Based Drug Design; X. Li, L. W. Tari, D. C. Bensen, M. Trzoss, T. Lam, J. Zhang, Z. Chen, S-J. Lee, M. Cunningham, B. Kwan, K. Nelson, M. Stidham, V. Brown-Driver, G. Hough, D. Phillipson, T. Nguyen, F. Lightstone, S. Wong, K. J. Shaw, J. Finn
F-2018: Antibacterial Agents Targeting DNA Gyrase B and Topoisomerase IV: Optimization of Gram-Negative Antibacterial Activity and Drug Properties; J. Finn, M. Trzoss, X. Li, D. C. Bensen, T. Lam, J. Zhang, Z. Chen, S-J. Lee, M. Cunningham, K. Nelson, A. Castellano, B. Kwan, M. Stidham, V. Brown-Driver, T. Nguyen, F. Lightstone, S. Wong, K. J. Shaw, L. Tari
F-2018a: Antibacterial Agents Targeting DNA Gyrase B and Topoisomerase IV: Design of Compounds with Broad-Spectrum Gram-Negative Antibacterial Activity; L. W. Tari, X. Li, D. C. Bensen, M. Trzoss, T. Lam, J. Zhang, Z. Chen, S-J. Lee, M. Cunningham, K. Nelson, M. Stidham, V. Brown-Driver, B. Kwan, S. Rodriguez, T. Nguyen, F. Lightstone, S. Wong, K. J. Shaw, J. Finn
F-2019: Potent Activity of Novel Gyrase/Topoisomerase Inhibitors Against Gram-Negative and Gram-Positive Pathogens with Important Resistance Phenotypes; C. M. Pillar, L. Stapert, M. A. Marchak, D. L. Shinabarger
F-2020: Microbiological Profile of Novel Inhibitors of DNA Gyrase and Topoisomerase IV Against Gram-Negative Pathogens; K. Nelson, A. Castellano, S. Farkas, V. Brown-Driver, K. J. Shaw
F-2021: In Vitro Activity of Novel Gyrase Inhibitor Antimicrobials Against Clinical Pseudomonas aeruginosa Isolates; P. R. Tessier, D. Nicolau
F-2022: Antimicrobial Activity and in vivo Efficacy of Novel GyrB/ParE Inhibitors versus Burkholderia pseudomallei; V. Brown-Driver, R. Bowen, N. L. Podnecky, N. Marlenee, X. Li, K. J. Shaw, H. P. Schweizer
F-2023: Broad Spectrum Activity of Novel, Dual Targeting Inhibitors of Bacterial DNA Gyrase and Topoisomerase IV Against Biodefense Pathogens; V. Brown-Driver, K. Montgomery, G. Vanier, K. Nelson, K. J. Shaw, P. J. Jackson
F-2024: Advanced Microbiological Profile of New DNA Gyrase/Topoisomerase IV Inhibitors; V. Brown-Driver, A. Castellano, K. Nelson, X. Li, T. Lam, M. Trzoss, J. Zhang, Z. Chen, S. Lee, K. J. Shaw, J. Finn
F-2025: Selection and Characterization of E. coli Mutants with Reduced Susceptibility to Novel DNA Gyrase/Topoisomerase IV Inhibitors; J. Locke, A. Castellano, S. Farkas, V. Brown-Driver, K. J. Shaw
F-2026: Comparative Pharmacokinetics of Novel Inhibitors of DNA Gyrase/Topoisomerase IV; V. S. Ong, V. Brown-Driver, C. L. Hall, G. W. Hough, K. Nelson, M. Cunningham
F-2027: Use of Microdosing and Accelerator Mass Spectrometry to Evaluate the Pharmacokinetics of a Novel GyrB/ParE Inhibitor; M. A. Malfatti, V. Lao, K. W. Turteltaub, C. L. Hall, V. S. Ong
F-2028: Activity of Novel, Dual Targeting Inhibitors of Bacterial DNA Gyrase and Topoisomerase IV in Murine Infection Models; T. M. Murphy, M. A. Blair, S. Little, A. Taylor, A. Slee, V. Brown-Driver, K. J. Shaw
F-2029In Vitro Activity and Pharmacodynamic (PD) evaluation of Dual Targeting Inhibitors of Bacterial DNA Gyrase and Topoisomerase IV (DTIs) against Extracellular and Intracellular Forms of ciprofloxacin-susceptible (CIPS) and ciprofloxacin-resistant (CIPR) Pseudomonas aeruginosa (PA) and Staphylococcus aureus (SA); P. M. Tulkens, S. Lemaire, D. Pierard, F. Van Bambeke
Symposium 228 Cfr-Mediated Resistance to Linezolid and Other Antibiotics (9:15 a.m. 9:45 a.m.)
Copies of these posters will be available on the Trius website following the ICAAC meeting: http://www.triusrx.com/trius-therapeutics-news-posters-publications-year.php.
About Trius Therapeutics
Trius Therapeutics, Inc. is a biopharmaceutical company focused on the discovery, development and commercialization of innovative antibiotics for life-threatening infections. The Company's lead investigational drug, tedizolid phosphate, is a once daily, IV and orally administered second generation oxazolidinone in Phase 3 clinical development for the treatment of acute bacterial skin and skin structure infections, or ABSSSI. Trius has two Special Protocol Assessments with the FDA for its two Phase 3 ABSSSI trials and has partnered with Bayer HealthCare for the development and commercialization of tedizolid phosphate outside of the U.S., Canada and the European Union. In addition to the Company's tedizolid phosphate clinical program, Trius has initiated IND-enabling studies for its Gyrase-B development candidate with potent activity against Gram-negative bacterial pathogens including multi-drug resistant strains of E. coli, Klebsiella, Acinetobacter and Pseudomonas. The Gyrase-B program is one of the two preclinical programs supported by federal contracts. For more information, visit www.triusrx.com.
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