Conference on 2nd Annual Diabetes and Diabetic Retinopathy

Conference on 2nd Annual Diabetes and Diabetic Retinopathy, Diabetes is becoming an epidemic and is expected to reach $86.9 billion by 20251; world health organisation predicts that 4.4% of the world population will have diabetes by 2030

Online PR News – 10-November-2010 – – Conference on 2nd Annual Diabetes and Diabetic Retinopathy
To be held at 7th - 8th February 2011, London, UK

Dr.Hans-Jürgen Wörle, Vice President, Therapeutic Area Head Metabolism,
Boehringer Ingelheim Pharma GmbH & Co. KG
Dr. Michael Mark, Vice president, Therapeutic Area CardioMetabolic Diseases Research,
Boehringer Ingelheim Pharma GmbH & Co. KG
Arash Tahbaz, MBChB, MRCP, Medical Advisor, Eli Lilly
Dr. David H Solomon, President , Chief Executive Officer, Zealand pharma A/S
Dr. Rob Jones, Senior Director, Medicinal Chemistry, Arena Pharmaceuticals
David M. Kendall, Chief Scientific and Medical Officer, American Diabetes Association
Dr. Araneo Barbara, Director of Complications Research, Juvenile Diabetes Research Foundation
Dr. Ennio Ongini, Vice President Research, NicOx
Dr. Selwyn Ho, Sr.Director, Marketing, Retina, Allergen EAME
Professor. P.M. Dodson, M.D, FRCP, FRCOphth Consultant, Diabetes & Medical Ophthalmology,
Birmingham Heartlands Hospital, Birmingham, UK
Professor Sue Lightman, Professor of Clinical Ophthalmology and Consultant Ophthalmologist, Institute of Ophthalmology, University College London / Institute of Ophthalmology and Moorfields Eye Hospital
Alireza Falahati-Nini, M.D, FACE President, Utah Endocrinology Associates Medical Director,
St. Mark’s Hospital Diabetes Center
Simon Taylor MA PhD FRCOphth, NIHR Clinical Lecturer in Ophthalmology, UCL Institute of Ophthalmology

Dear Colleague,

Diabetes is becoming an epidemic and is expected to reach $86.9 billion by 20251; world health organisation predicts that 4.4% of the world population will have diabetes by 2030. Of the 246 million people with diabetes about third have signs of diabetic retinopathy3 and about third of these might have vision –threatening retinopathy defined as severe retinopathy or macular oedema4.
Research is constantly going on to develop a better understanding of physiologic characteristics of type 1 and type 2. Recognition of the contribution of fasting and postprandial blood glucose levels to overall glycemia, new treatment approaches that focus on achieving tight glycemic control and other therapeutic options that allow the practitioner to develop treatments tailored to meet the individual patient needs are being addressed.
Visiongain’s 2nd Annual Diabetes and Diabetic Retinopathy conference is designed to bring together the industry experts to discuss every aspect of drug development for diabetes, from latest clinical development through to dealing with regulatory issues.

By attending this Conference on 2nd Annual Diabetes and Diabetic Retinopathy, you will:

• Assess new developments in currently used treatments –Human insulins and analogues,DPP-IV inhibitors, Sulphonylurea and Biguanide, Alpha-Glucosidase Inhibitor, GLP-1 agonist, SGLT inhibitor etc
• Gain insight about the future market trends in insulin, oral anti-diabetic and non insulin injections
• Find new treatments for diabetes
• Overcome challenges in developing novel anti-diabetic therapies
• Evaluate the latest clinical development for diabetic retinopathy
• Effectively target glycaemia and blood pressure levels for prevention of retinopathy development and progression
• Advance role of lipid lowering therapy
• Understand the new medical treatments in diabetic retinopathy –ocular therapy (laser photocoagulation)
• Explore emerging ophthalmic treatments –Glucocorticoids and the role of drug delivery systems in the management of Diabetic Macular Edema and Anti-VEGF therapy
• Examine the challenges in regulating development & approval of drugs in Diabetes
I look forward to meeting you at the conference

Best regards

Who will be there for Conference on 2nd Annual Diabetes and Diabetic Retinopathy ?

Presidents, Chief Executives, Chief Scientific Officers, Chief Operating Officers, Senior Vice Presidents, Vice Presidents, Heads, Senior Directors, Directors, Clinicians, Principal Scientists, Principal Investigators, Managers, Project/Team Leaders in:
• Diabetes & Obesity, Pre-Clinical and Clinical R&D
• Retinal Diseases
• Ophthalmology, Visual Science and Vision Research
• Endocrinology and Metabolic Diseases
• Cardiovascular and Gastrointestinal Diseases
• Anti-Diabetic Agents & Advanced Diabetes Systems
• Drug Development
• Monoclonal Antibodies
• Molecular Neuroscience
• New Products Global Marketing
• Business Development, Licensing & Partnership
• Venture Capital
• Regulatory Affairs

Conference on 2nd Annual Diabetes and Diabetic Retinopathy Day 1
2nd Annual Diabetes and Diabetic Retinopathy
Monday 7th February 2011

09:00 Registration and refreshments
09:30 Opening address from the chair
09:40 Perspective on emerging treatments for diabetic retinal disease and the challenges for prevention and treatment
• Overview on diabetes
• JDRF view of clinical unmet need
- Reach out to adolescents and adults
- Screening and prevention
- Sight-sparing treatment
• JDRF view of gaps in research
- Collaboration
- Diagnostics
- Therapies
- Policy and reimbursement
- Education
Dr
.Barbara A. Araneo
Scientific Program Director - Complications Therapies
Juvenile Diabetes Research Foundation
10:20 Finding new treatments for diabetes
• DPP4- inhibitors
• SGLT-2 inhibitors
Dr
. Michael Mark
Vice president, Therapeutic Area Cardio Metabolic Disease
Boehringer Ingelheim Pharma GmbH & Co. KG
11:00 Morning refreshments
11:20 Examine the challenges in regulating development & approval of drugs in diabetes
• Implication of the new FDA CV guidance, can one still develop gluco-centric compounds?
• What is feasible size of a phase III program in the light of the new requirements?
• What patients should be included and at what stage of the CDP?
Dr
. Hans-Jürgen Wörle
Vice President, Therapeutic Area Head Metabolism
C MED Clinical Development & Medical Affairs
Boehringer Ingelheim Pharma GmbH & Co. KG
12:00 GLP-1—new treatment paradigms in diabetes—The Zealand Pharma Story
• Overview of GLP-1s
• The discovery at Zealand of Lixisenatide and its commercialisation by sanofi-aventis
• New directions of GLP-1s in the treatment of diabetes and related obesity
Dr
.David H Solomon
President, Chief Executive Officer
ZEALAND Pharma A/S
12:40 Networking lunch

13:40 GPR119 Agonists for the treatment of Type 2 Diabetes
• Overview of GPR119
• Mechanism of glycemic control
• Clinical status
Dr
Rob Jones
Senior Director, Medicinal Chemistry
Arena Pharmaceuticals
14:20 Emerging therapies -GLP1 receptor agonists
Arash
TAHBAZ MBChB, MRCP
Medical Advisor
Eli Lilly
15:00 Afternoon Refreshments
15:20 Treatment targets in diabetes: where do we stand following ACCORD?
• Review the history of studies in intensive glycemic control (from UGDP to ACCORD) and discuss the impact of these interventions on microvascular complications in diabetes
• Discuss the relative impact of early vs late intervention and its impact on microvascular complications risk
• Outline the findings of more recently published studies of more intensive glycemic control (ACCORD, ADVANCE and VADT) as relates to retinal complications of diabetes
• Review the risk-benefit of more intensive treatment strategies as relates to diabetes intervention
• Discuss current treatment targets for glucose, lipids and blood pressure following completion of the ACCORD trial
David
M. Kendall, MD
Chief Scientific and Medical Officer
American Diabetes Association
16:00 Review of current and emerging - DPP-4 Inhibitors and GLP-1 Analogs
• Review of the Physiology of Incretins (GLP-1 and GIP) as well as
DPP-4 Inhibitors
• Review of current and emerging drugs from the GLP-1 and DPP-4 Inhibitor classes
• Review of current evidence for “Beta-Cell Preservation” in animals (and Humans?)
• Review of current evidence of positive effect of these two classes on cardiovascular health
• Review of long-term data (5-year +) on sustainability of diabetes management with these two new classes
• Potential Adverse effects and why?
Alir
eza Falahati-Nini, M.D., FACE
President, Utah Endocrinology Associates
Medical Director, St. Mark’s Hospital Diabetes Center
16:40 Closing remarks from the chair

16:50 Networking drinks
Take your discussions further and build new relationships in a relaxed and informal setting

Conference on 2nd Annual Diabetes and Diabetic Retinopathy Day 2
2nd Annual Diabetes and Diabetic Retinopathy
Tuesday 8th February 2011

09:00 Registration and refreshments
09:30 Opening address from the chair
09:40 Role of lipid lowering therapy in
diabetes retinopathy
 • How do lipids influence eye disease?
 • Relationship of lipids and diabetic retinopathy
 • Potential mechanisms of retinal damage by lipids
 • Treatment of retinopathy with lipid lowering drugs :
statins and fibrates
• CARDS,FIELD,ACCORD-EYE Studies
• Conclusion
PROFESSOR.
P.M. DODSON, MD, FRCP, FRCOphth
Consultant, Diabetes & Medical Ophthalmology, Departments of Diabetes, Ophthalmology, & Heart of England Diabetic Retinopathy Screening Centre
Birmingham Heartlands Hospital, Birmingham, UK
10:20 Nitric oxide-donating glucocorticoids for effective and safe treatment of diabetic macular edema
• Targeting nitric oxide (NO) for the treatment of eye diseases
• Nitric oxide and IOP lowering
• Nitric oxide and oxygen saturation of the retina and ONH
• Potential of NO-donating glucocorticoids
Dr.Ennio Ongini
Vice President Research
NicOx
11:00 Morning refreshments
11:20 Assessing the latest clinical developments for
diabetic retinopathy
• Overview of diabetic retinopathy
• Biochemical changes VEGF pathways
12:00 Emerging ophthalmic therapies: Glucocorticoids and the role of drug delivery systems in the management of diabetic macular edema.
• The pathophysiology of diabetic macular edema (DME) has a clear inflammatory component
• Glucocorticoids have been a key part of the armamentarium for the management of DME, both in monotherapy and in combination with other modalities
• Differences in the glucocorticoid molecular structure, routes of administration and pharmacokinetic profiles may result in clinically relevant differences
• In a long-term, chronic disease such as DME, Glucocorticoids in long duration drug delivery systems may play a role in reducing the burden of drug administration to patients, physicians and health care systems
Dr
.Selwyn Ho
Sr.Director, Marketing, Retina
Allergen EAME

12:40 Networking lunch
13:40 Emerging ophthalmic treatments
-Anti-VEGF therapy
• Rationale for anti-VEGF agents in diabetic macular edema
• Types of anti-VEGF agents in use
• Results of the main clinical studies./ trials
• Comparison with other treatment modalities
• Their use in clinical practise
Professor Sue Lightman
Professor of Clinical Ophthalmology
UCL/Institute of Ophthalmology and
Moorfields Eye Hospital
14:20 Emerging medical treatments -Ocular therapy
• Advances in laser for proliferative disease
• Advances in laser for diabetic macular oedema
• Where are we now? - results of the clinical trials
• Role of vitreoretinal surgery
Simon
Taylor MA PhD FRCOphth
NIHR Clinical Lecturer in Ophthalmology
UCL Institute of Ophthalmology
15:00 Afternoon refreshments
15:20 Systemic therapy in treatment of diabetic retinopathy
• Target glycaemia and blood pressure levels of effective prevention of retinopathy development and progression
• Efficiency of hypoglycaemic and blood pressure lowering agents
16:00 Pharmacological inhibition of diabetic retinopathy
• Aldose reductase inhibitors
• Anti-inflammatory methods
• Protein kinase C activation and its pharmacological inhibition in
vascular disease
16:40 Chair’s closing remarks
16:50 End of conference

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